Antimicrobial Activities of Chitosan Derivatives

• Main Authors: Cristina Ardean (Author), Corneliu Mircea Davidescu (Author), Nicoleta Sorina Nemeş (Author), Adina Negrea (Author), Mihaela Ciopec (Author), Narcis Duteanu (Author), Petru Negrea (Author), Daniel Duda-Seiman (Author), Delia Muntean (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/pharmaceutics13101639; 1999-4923
• Keywords: chitosan; antibacterial activities; antifungal activities; functionalization by impregnation; Pharmacy and materia medica; RS1-441
• Source: Pharmaceutics, Vol 13, Iss 10, p 1639 (2021)

Considering the challenge created by the development of bacterial and fungal strains resistant to multiple therapeutic variants, new molecules and materials with specific properties against these microorganisms can be synthesized, like those synthesized from biopolymers such as chitosan with improved antimicrobial activities. Antimicrobial activities of seven obtained materials were tested on four reference strains belonging to American Type Culture Collection. The best antimicrobial activity was obtained by functionalization by impregnation of chitosan with quaternary ammonium salts, followed by that obtained by functionalization of chitosan with phosphonium. The lowest antibacterial and antifungal effects were expressed by Ch-THIO and Ch-MBT, but new materials obtained with these extractants may be precursors with a significant role in the direct control of active molecules, such as cell growth factors or cell signaling molecules.