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Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against VEGFR-2 and an acceptable range of the drug-likenes...

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Main Authors:	Reda G. Yousef (Author), Albaraa Ibrahim (Author), Mohamed M. Khalifa (Author), Wagdy M. Eldehna (Author), Ibraheem M. M. Gobaara (Author), Ahmed B. M. Mehany (Author), Eslam B. Elkaeed (Author), Aisha A. Alsfouk (Author), Ahmed M. Metwaly (Author), Ibrahim H. Eissa (Author)
Format:	Book
Published:	Taylor & Francis Group, 2022-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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