Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review

Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use o...

Full description

Saved in:
Bibliographic Details
Main Authors: Kamylla Rafaella Sena Albuquerque (Author), Nívea Maria Pacheco (Author), Thalia del Rosario Loyo Casao (Author), Fabiana Cristina Silveira Alves de Melo (Author), Rômulo Dias Novaes (Author), Reggiani Vilela Gonçalves (Author)
Format: Book
Published: Hindawi Limited, 2018-01-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_8d26f0aa7a094caab32c6bff32726d8f
042 |a dc 
100 1 0 |a Kamylla Rafaella Sena Albuquerque  |e author 
700 1 0 |a Nívea Maria Pacheco  |e author 
700 1 0 |a Thalia del Rosario Loyo Casao  |e author 
700 1 0 |a Fabiana Cristina Silveira Alves de Melo  |e author 
700 1 0 |a Rômulo Dias Novaes  |e author 
700 1 0 |a Reggiani Vilela Gonçalves  |e author 
245 0 0 |a Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review 
260 |b Hindawi Limited,   |c 2018-01-01T00:00:00Z. 
500 |a 0962-9351 
500 |a 1466-1861 
500 |a 10.1155/2018/6797924 
520 |a Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use of natural products to treat this cancer. We performed a systematic review to compile the results of studies carried out in murine models and investigated the effect of plant extracts on melanoma treatment. Papers were selected in MEDLINE/Pubmed and Scopus according to the PRISM statement. Search filters were developed using three parameters: plant extract, melanoma, and animal model. The 35 identified studies were all submitted to the criteria described in the ARRIVE guidelines. The different extracts showed antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activity, and also proved to be effective in cell cycle modulation and apoptosis evasion. Bias analysis evidenced the absence of standardized experimental designs, as well as failures in statistical tests and in the presentation of results. The analysis of the studies suggests that the use of plant extracts is effective for the treatment of melanoma in murine models. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2018 (2018) 
787 0 |n http://dx.doi.org/10.1155/2018/6797924 
787 0 |n https://doaj.org/toc/0962-9351 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/8d26f0aa7a094caab32c6bff32726d8f  |z Connect to this object online.