THROMBOPHILIA AND FAILURES OF EXTRACORPORAL FERTILIZATION
Objective. It was study the frequency and a range of the genetic and acquired thrombophilia at patients with failures of in-vitro fertilization (IVF). Materials and methods. 115 women who had from 1 to 9 unsuccessful attempts of IVF were examined. Genetic thrombotic mutations, circulation AFA and le...
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IRBIS LLC,
2016-06-01T00:00:00Z.
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| Summary: | Objective. It was study the frequency and a range of the genetic and acquired thrombophilia at patients with failures of in-vitro fertilization (IVF). Materials and methods. 115 women who had from 1 to 9 unsuccessful attempts of IVF were examined. Genetic thrombotic mutations, circulation AFA and level of a gomotsistein (an immunofermental method) were defined. Results. High frequency of the genetic forms of a thrombophilia influencing the level of an endogenous fibrinoliz (polymorphisms of plasminogen activator inhibitor-1 (PAI-1) - 66.9%, the tissue-type plasminogen activator (TPA) - 60.9%, fibrinogen - 47.8%), in combination with circulation of antiphospholipid antibodies (40.9%) is revealed. Conclusion. In the program of preparation for IVF of patients with unsuccessful attempts it is necessary to consider possible presence of the genetic and acquired thrombophilia. |
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| Item Description: | 2313-7347 2500-3194 10.17749/2070-4968.2015.9.3.017-021 |