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Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1-3 from Glycyrrhiza uralensis had inhibitor...

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Bibliographic Details
Main Authors: Jang Hoon Kim (Author), Yea-In Park (Author), Mok Hur (Author), Woo Tae Park (Author), Youn-Ho Moon (Author), Yun-Chan Huh (Author), Tae IL Kim (Author), Min Hye Kang (Author), Jong Seong Kang (Author), Chong Woon Cho (Author), Junsoo Park (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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Summary:Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1-3 from Glycyrrhiza uralensis had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds 1-3 are inhibitors of 3CLpro and HCoV-OC43 proliferation.
Item Description:10.1080/14756366.2023.2242704
1475-6374
1475-6366

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