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Differences in Drug-Susceptibility Patterns between <i>Mycobacterium avium</i>, <i>Mycobacterium intracellulare</i>, and <i>Mycobacterium chimaera</i> Clinical Isolates: Prospective 8.5-Year Analysis by Three Laboratories

<b>Background</b>: It has been suggested that <i>Mycobacterium avium</i>, <i>Mycobacterium intracellulare</i>, and <i>M. chimaera</i> have differential drug susceptibility patterns. We prospectively analyzed and compared the drug susceptibility pattern...

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Main Authors:	Mariana Fernandez-Pittol (Author), Sara Batista-Arnau (Author), Angely Román (Author), Lorena San Nicolás (Author), Laura Oliver (Author), Olga González-Moreno (Author), José Antonio Martínez (Author), Rosanel Amaro-Rodríguez (Author), Néstor Soler (Author), Amadeu Gené (Author), Araceli González-Cuevas (Author), Griselda Tudó (Author), Julian Gonzalez-Martin (Author)
Format:	Book
Published:	MDPI AG, 2022-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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Summary:	<b>Background</b>: It has been suggested that <i>Mycobacterium avium</i>, <i>Mycobacterium intracellulare</i>, and <i>M. chimaera</i> have differential drug susceptibility patterns. We prospectively analyzed and compared the drug susceptibility patterns among these species over an 8.5-year period. <b>Methods</b>: A microdilution method (Slomyco<sup>®</sup>) was performed for drug susceptibility testing of 402 <i>M. avium</i>, 273 <i>M. intracellulare</i>, and 139 <i>M. chimaera</i> clinical isolates. <b>Results</b>: <i>M. avium</i> showed significantly higher resistance to moxifloxacin, ciprofloxacin, rifampicin, ethambutol, streptomycin, linezolid, cotrimoxazole, and clarithromycin. <i>M. avium</i> also showed higher minimum inhibitory concentrations (MIC) than <i>M. intracellulare</i> and <i>M. chimaera</i> against all drugs except ethionamide, to which <i>M. intracellulare</i> and <i>M. chimaera</i> showed greater resistance. <b>Conclusions</b>: Our series demonstrated differential drug resistance patterns among the most frequent <i>M. avium</i> complex species. <i>M. avium</i> was more resistant than <i>M. intracellulare</i> and <i>M. chimaera</i> versus eight antibiotics and showed greater MIC values to most of the antibiotics studied. These data suggest that knowledge of the local distribution and susceptibility profiles of these pathogens is essential for adequate clinical management.
Item Description:	10.3390/antibiotics12010064 2079-6382