Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats
Background : Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient's age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential diffe...
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| Main Authors: | , , |
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| Format: | Book |
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Medical Association of Pharmacopuncture Institute,
2021-08-01T00:00:00Z.
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| Summary: | Background : Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient's age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats. Methods : In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats. Results : Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats. Conclusion : These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats. |
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| Item Description: | 2005-2901 10.51507/j.jams.2021.14.4.167 |