Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells

• Main Authors: Yuanchun Fan (Author), Huimin Cheng (Author), Yueping Liu (Author), Shihao Liu (Author), Scott Lowe (Author), Yaru Li (Author), Rachel Bentley (Author), Bethany King (Author), John Pocholo W. Tuason (Author), Qin Zhou (Author), Chenyu Sun (Author), Hui Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The occurrence and development of solid tumors depend on the blood supply in the tumor microenvironment (TME). Blocking angiogenesis is a new therapeutic strategy to inhibit tumor growth. The anti-angiogenic drug bevacizumab has been approved for gynecological malignancies, especially fo...