Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice

• Main Authors: Jennifer C. Wong (Author), Stacey B.B. Dutton (Author), Stephen D. Collins (Author), Steven Schachter (Author), Andrew Escayg (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seizures (FSs), refractory afebrile epilepsy, cognitiv...