Transport Characteristics of Tryptanthrin and its Inhibitory Effect on P-gp and MRP2 in Caco-2 Cells

• Main Authors: Xingang Zhu (Author), Xuelian Zhang (Author), Guo Ma (Author), Junkai Yan (Author), Honghai Wang (Author), Qing Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Tryptanthrin, an indole quinazoline alkaloid with multiple medical activities, has been recently under preclinical development as an anti-tuberculosis and anti-tumor drug. The aims of this study are to characterize the intestinal transport of tryptanthrin in Caco-2 cells, to determine wheth...