Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status

• Main Authors: Yuting Cui (Author), Yue Xiong (Author), Hua Li (Author), Mengqi Zeng (Author), Yan Wang (Author), Yuan Li (Author), Xuan Zou (Author), Weiqiang Lv (Author), Jing Gao (Author), Ruijun Cao (Author), Lingjie Meng (Author), Jiangang Long (Author), Jiankang Liu (Author), Zhihui Feng (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NF-E2-related factor 2 (Nrf2), the key transcription regulator of phase II enzymes, has been considered beneficial for neuronal protection. We previously designed a novel chalcone analog, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), that could specifically activate Nrf2 i...