Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients

• Main Authors: Tur K (Author), Güçlü A (Author)
• Format: Book
• Published: Dove Medical Press, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1178-7031
• Keywords: malnutrition inflammation score; malnutrition; crp/albumin ratio; hemodialysis; Pathology; RB1-214; Therapeutics. Pharmacology; RM1-950
• Source: Journal of Inflammation Research, Vol Volume 17, Pp 9325-9333 (2024)

Kağan Tur,1 Aydın Güçlü2 1Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey; 2Ahi Evran University Faculty of Medicine, Nephrology Department, Kirsehir, TurkeyCorrespondence: Kağan Tur, Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey, Tel [phone], Email [e-mail]; [e-mail]: This study aimed to investigate the relationship between the Malnutrition Inflammation Score (MIS) and the C-reactive protein/albumin ratio (CAR) in patients undergoing hemodialysis (HD).Materials and Methods: Sixty-six End-Stage Renal Disease (ESRD) patients on maintenance hemodialysis were recruited for the study. Malnutrition Inflammation Score, biochemical parameters, and C-reactive protein/albumin ratio were analyzed.Results: The mean age of the participants was 56.47 ± 17.3 years. A statistically significant positive correlation was found between the CRP/albumin ratio and MIS ≥ 7 (r = 0.413, p = 0.026), CRP and MIS ≥ 7 (r = 0.388, p = 0.038) and a negative correlation between albumin and MIS (r = − 0.511, p = 0.005). Additionally, MIS was negatively correlated with hemoglobin (r = − 0.412, p = 0.026) and creatinine (r = − 0.568, p = 0.001), while a positive correlation was found between MIS and ferritin (r = 0.584, p = 0.001) for MIS ≥ 7. A multiple regression ANOVA model confirmed a significant association between CAR, CRP, albumin, and MIS (F = 6.432, p = 0.002), with significant contributions from CAR (p = 0.003), albumin (p = 0.008), and CRP (p = 0.003).Conclusion: Our study is the first to show an independent association between CAR and MIS in hemodialysis patients. The CRP/albumin ratio can serve as a valuable indicator of malnutrition in this population, providing a reliable tool for assessing nutritional status.Keywords: malnutrition inflammation score, malnutrition, CRP/albumin ratio, hemodialysis