A novel architecture for achieving high drug loading in amorphous spray dried dispersion tablets

• Main Authors: Deanna M. Mudie (Author), Stephanie Buchanan (Author), Aaron M. Stewart (Author), Adam Smith (Author), Kimberly B. Shepard (Author), Nishant Biswas (Author), Derrick Marshall (Author), Alyssa Ekdahl (Author), Amanda Pluntze (Author), Christopher D. Craig (Author), Michael M. Morgen (Author), John M. Baumann (Author), David T. Vodak (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although Amorphous Solid Dispersions (ASDs) effectively increase bioavailability, tablet mass can be high due to the large fraction of excipients needed to stabilize the amorphous drug in the solid state, extend drug supersaturation in solution and achieve robust manufacturability. The aim of this w...