Vaccination Status and In-hospital Mortality Among Adults With COVID-19 in Jakarta, Indonesia: A Retrospective Hospital-based Cohort Study

Objectives Prospective studies on vaccination status and mortality related to coronavirus disease 2019 (COVID-19) in low-resource settings are still limited. We assessed the association between vaccination status (full, partial, or none) and in-hospital mortality among COVID-19 patients at most hosp...

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Main Authors: Hotma Martogi Lorensi Hutapea (Author), Pandji Wibawa Dhewantara (Author), Anton Suryatma (Author), Raras Anasi (Author), Harimat Hendarwan (Author), Mondastri Korib Sudaryo (Author), Dwi Gayatri (Author)
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Published: Korean Society for Preventive Medicine, 2023-11-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hotma Martogi Lorensi Hutapea  |e author 
700 1 0 |a Pandji Wibawa Dhewantara  |e author 
700 1 0 |a Anton Suryatma  |e author 
700 1 0 |a Raras Anasi  |e author 
700 1 0 |a Harimat Hendarwan  |e author 
700 1 0 |a Mondastri Korib Sudaryo  |e author 
700 1 0 |a Dwi Gayatri  |e author 
245 0 0 |a Vaccination Status and In-hospital Mortality Among Adults With COVID-19 in Jakarta, Indonesia: A Retrospective Hospital-based Cohort Study 
260 |b Korean Society for Preventive Medicine,   |c 2023-11-01T00:00:00Z. 
500 |a 1975-8375 
500 |a 2233-4521 
500 |a 10.3961/jpmph.23.360 
520 |a Objectives Prospective studies on vaccination status and mortality related to coronavirus disease 2019 (COVID-19) in low-resource settings are still limited. We assessed the association between vaccination status (full, partial, or none) and in-hospital mortality among COVID-19 patients at most hospitals in Jakarta, Indonesia during the Delta predomination wave. Methods We conducted a retrospective cohort study among hospitalized COVID-19 patients who met the study criteria (>18 years old and admitted for inpatient treatment because of laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection). We linked individual-level data in the hospital admission database with vaccination records. Several socio-demographic and clinical characteristics were also analyzed. A Cox proportional hazards regression model was used to explore the association between vaccination status and in-hospital mortality in this patient group. Results In total, 40 827 patients were included in this study. Of these, 70% were unvaccinated (n=28 543) and 19.3% (n=7882) died during hospitalization. The mean age of the patients was 49 years (range, 35-59), 53.2% were female, 22.0% had hypertension, and 14.2% were treated in the intensive care unit, and the median hospital length of stay across the group was 9 days. Our study showed that the risk of in-hospital mortality among fully and partially vaccinated patients was lower than among unvaccinated adults (adjusted hazard ratio [aHR], 0.43; 95% confidence interval [CI], 0.40 to 0.47 and aHR, 0.70; 95% CI, 0.64 to 0.77, respectively). Conclusions Vaccinated patients had fewer severe outcomes among hospitalized adults during the Delta wave in Jakarta. These features should be carefully considered by healthcare professionals in treating adults within this patient group. 
546 |a EN 
690 |a covid-19 
690 |a delta variant 
690 |a hospitalization 
690 |a mortality 
690 |a vaccination 
690 |a Medicine 
690 |a R 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Journal of Preventive Medicine and Public Health, Vol 56, Iss 6, Pp 542-551 (2023) 
787 0 |n http://jpmph.org/upload/pdf/jpmph-23-360.pdf 
787 0 |n https://doaj.org/toc/1975-8375 
787 0 |n https://doaj.org/toc/2233-4521 
856 4 1 |u https://doaj.org/article/8e19cfd286d1439d80de3d64b3efc071  |z Connect to this object online.