A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been scientifically proven. The addition of propolis...

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Main Authors: Bianca Aparecida Martin (Author), Camila Nunes Lemos (Author), Luciana Facco Dalmolin (Author), Caroline Arruda (Author), Íris Sperchi Camilo Brait (Author), Maurílio de Souza Cazarim (Author), Estael Luzia Coelho da Cruz-Cazarim (Author), Paula Carolina Pires Bueno (Author), Maurílio Polizello Júnior (Author), Leonardo Régis Leira Pereira (Author), Renata Nahas Cardili (Author), Renata Fonseca Vianna Lopez (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Bianca Aparecida Martin  |e author 
700 1 0 |a Camila Nunes Lemos  |e author 
700 1 0 |a Luciana Facco Dalmolin  |e author 
700 1 0 |a Caroline Arruda  |e author 
700 1 0 |a Íris Sperchi Camilo Brait  |e author 
700 1 0 |a Maurílio de Souza Cazarim  |e author 
700 1 0 |a Estael Luzia Coelho da Cruz-Cazarim  |e author 
700 1 0 |a Paula Carolina Pires Bueno  |e author 
700 1 0 |a Maurílio Polizello Júnior  |e author 
700 1 0 |a Leonardo Régis Leira Pereira  |e author 
700 1 0 |a Renata Nahas Cardili  |e author 
700 1 0 |a Renata Fonseca Vianna Lopez  |e author 
245 0 0 |a A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream 
260 |b MDPI AG,   |c 2021-08-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics13091346 
500 |a 1999-4923 
520 |a Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been scientifically proven. The addition of propolis has the potential to impart anti-inflammatory properties to cold cream. However, in high concentrations, propolis can trigger allergic reactions. Thus, the objective of this work was to develop a cold cream formulation based on purified beeswax containing the same amount of green propolis present in raw beeswax. The impact of adding this low propolis concentration to cold cream on AD control was evaluated in patients compared to cold cream without added propolis (CBlank). Raw beeswax was chemically characterized to define the propolis concentration added to the propolis-loaded cold cream (CPropolis). The creams were characterized as to their physicochemical, mechanical, and rheological characteristics. The effect of CPropolis and CBlank on the quality of life, disease severity, and skin hydration of patients with AD was evaluated in a triple-blind randomized preclinical study. Concentrations of 34 to 120 ng/mL of green propolis extract reduced TNF-α levels in LPS-stimulated macrophage culture. The addition of propolis to cold cream did not change the cream's rheological, mechanical, or bioadhesive properties. The preclinical study suggested that both creams improved the patient's quality of life. Furthermore, the use of CPropolis decreased the disease severity compared to CBlank. 
546 |a EN 
690 |a raw beeswax 
690 |a atopic dermatitis 
690 |a green propolis 
690 |a anti-inflammatory property 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 13, Iss 9, p 1346 (2021) 
787 0 |n https://www.mdpi.com/1999-4923/13/9/1346 
787 0 |n https://doaj.org/toc/1999-4923 
856 4 1 |u https://doaj.org/article/8e1fffe719ac4f3f80a4ea4e58bb9f70  |z Connect to this object online.