Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis
Although microglia are associated with chronic pain, the role of spinal microglia in the regulation of itch remains unclear. In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2023-12-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8e22f96b121c4a6b8de8a4fc9fb00720 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Fumihiro Saika |e author |
| 700 | 1 | 0 | |a Yohji Fukazawa |e author |
| 700 | 1 | 0 | |a Shiroh Kishioka |e author |
| 700 | 1 | 0 | |a Norikazu Kiguchi |e author |
| 245 | 0 | 0 | |a Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis |
| 260 | |b Elsevier, |c 2023-12-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2023.09.004 | ||
| 520 | |a Although microglia are associated with chronic pain, the role of spinal microglia in the regulation of itch remains unclear. In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout the spinal cord after the topical application of IMQ. Furthermore, the mRNA expression of microglial markers and inflammatory mediators was upregulated. Ablation of itch-related sensory neurons using resiniferatoxin decreased itch-related scratching behavior and the number of hypertrophic microglia in the spinal dorsal horn. Conclusively, sensory neuron input may partially contribute to spinal microglial activation after IMQ application. | ||
| 546 | |a EN | ||
| 690 | |a Itch | ||
| 690 | |a Dorsal horn | ||
| 690 | |a Glia | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 153, Iss 4, Pp 183-187 (2023) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861323000579 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8e22f96b121c4a6b8de8a4fc9fb00720 |z Connect to this object online. |