Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry
<p>Abstract</p> <p>Background</p> <p>A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in <it>CTNNBL1 </it>are associated with obesity and increased fat mass. We analysed the respectiv...
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2009-02-01T00:00:00Z.
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| 001 | doaj_8e24bae71eb44aaaacf9afa8fc903e06 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Wichmann H-Erich |e author |
| 700 | 1 | 0 | |a Illig Thomas |e author |
| 700 | 1 | 0 | |a Heid Iris M |e author |
| 700 | 1 | 0 | |a Grallert Harald |e author |
| 700 | 1 | 0 | |a Friedel Susann |e author |
| 700 | 1 | 0 | |a Müller Timo D |e author |
| 700 | 1 | 0 | |a Scherag André |e author |
| 700 | 1 | 0 | |a Greene Brandon |e author |
| 700 | 1 | 0 | |a Vogel Carla IG |e author |
| 700 | 1 | 0 | |a Schäfer Helmut |e author |
| 700 | 1 | 0 | |a Hebebrand Johannes |e author |
| 700 | 1 | 0 | |a Hinney Anke |e author |
| 245 | 0 | 0 | |a Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| 260 | |b BMC, |c 2009-02-01T00:00:00Z. | ||
| 500 | |a 10.1186/1471-2350-10-14 | ||
| 500 | |a 1471-2350 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in <it>CTNNBL1 </it>are associated with obesity and increased fat mass. We analysed the respective SNPs in data from our previously published GWA for early onset obesity (case-control design), in GWA data from a population-based cohort of adults, and in an independent family-based obesity study. We investigated whether variants in <it>CTNNBL1 </it>(including rs6013029) and in three other genes (<it>SH3PXD2B</it>, <it>SLIT3 </it>and <it>FLJ42133</it>,) were associated with obesity.</p> <p>Methods</p> <p>The GWA studies were carried out using Affymetrix<sup>® </sup>SNP Chips with approximately 500,000 markers each. In the families, SNP rs6013029 was genotyped using the TaqMan<sup>® </sup>allelic discrimination assay. The German case-control GWA included 487 extremely obese children and adolescents and 442 healthy lean individuals. The adult GWA included 1,644 individuals from a German population-based study (KORA). The 775 independent German families consisted of extremely obese children and adolescents and their parents.</p> <p>Results</p> <p>We found no evidence for an association of the reported variants in <it>CTNNBL1 </it>with early onset obesity or increased BMI. Further, in our family-based study we found no evidence for over-transmission of the rs6013029 risk-allele T to obese children. Additionally, we found no evidence for an association of <it>SH3PXD2B</it>, <it>SLIT3 and FLJ42133 </it>variants in our two GWA samples.</p> <p>Conclusion</p> <p>We detected no confirmation of the recent association of variants in <it>CTNNBL1 </it>with obesity in a population of Central European ancestry.</p> | ||
| 546 | |a EN | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n BMC Medical Genetics, Vol 10, Iss 1, p 14 (2009) | |
| 787 | 0 | |n http://www.biomedcentral.com/1471-2350/10/14 | |
| 787 | 0 | |n https://doaj.org/toc/1471-2350 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8e24bae71eb44aaaacf9afa8fc903e06 |z Connect to this object online. |