Engineered packaging cell line for the enhanced production of baboon-enveloped retroviral vectors

• Main Authors: Denise Klatt (Author), Lucia Sereni (Author), Boya Liu (Author), Pietro Genovese (Author), Axel Schambach (Author), Els Verhoeyen (Author), David A. Williams (Author), Christian Brendel (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The baboon endogenous retrovirus (BaEV) glycoprotein is superior to the commonly used vesicular stomatitis virus glycoprotein (VSVg) for retroviral gene transfer into resting hematopoietic stem cells and lymphocyte populations. The derivative BaEVRLess (lacking the R domain) produces higher viral ti...