Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13
Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them t...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Elsevier,
2011-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them to act as tumor-homing peptides for the targeted delivery of anti-tumor drugs to tumor neovascular endothelial cells and tumor cells. This article reviews the literature and recent developments related to APN/CD13, its role in tumor growth and some anti-tumor drug delivery systems containing NGR peptides designed to target APN/CD13. |
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| Item Description: | 2211-3835 2211-3843 10.1016/j.apsb.2011.06.002 |