Osthole: An up-to-date review of its anticancer potential and mechanisms of action

• Main Authors: Shaojie Yang (Author), Wanlin Dai (Author), Jingnan Wang (Author), Xiaolin Zhang (Author), Yuting Zheng (Author), Shiyuan Bi (Author), Liwei Pang (Author), Tengqi Ren (Author), Ye Yang (Author), Yang Sun (Author), Zhuyuan Zheng (Author), Shuodong Wu (Author), Jing Kong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1663-9812; 10.3389/fphar.2022.945627
• Keywords: osthole; anticancer; proliferation; apoptosis; metastasis; angiogenesis; Therapeutics. Pharmacology; RM1-950
• Source: Frontiers in Pharmacology, Vol 13 (2022)

With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years.