A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis
Objective: To prepare a novel nanoemulsion- Carbopol® 934 gel for Eugenol, in order to prevent the periodontitis. Material and methods: Spontaneous emulsification method was used for the preparation of nanoemulsion in which it contain Eugenol (oil phase), Tween-80 (surfactant), and PEG (co-surfactan...
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Elsevier,
2019-09-01T00:00:00Z.
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| 001 | doaj_8e4de1b66652485295f79d2d8bb5a3e5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Niyaz Ahmad |e author |
| 700 | 1 | 0 | |a Farhan Jalees Ahmad |e author |
| 700 | 1 | 0 | |a Sumit Bedi |e author |
| 700 | 1 | 0 | |a Sonali Sharma |e author |
| 700 | 1 | 0 | |a Sadiq Umar |e author |
| 700 | 1 | 0 | |a Mohammad Azam Ansari |e author |
| 245 | 0 | 0 | |a A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis |
| 260 | |b Elsevier, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 1319-0164 | ||
| 500 | |a 10.1016/j.jsps.2019.04.014 | ||
| 520 | |a Objective: To prepare a novel nanoemulsion- Carbopol® 934 gel for Eugenol, in order to prevent the periodontitis. Material and methods: Spontaneous emulsification method was used for the preparation of nanoemulsion in which it contain Eugenol (oil phase), Tween-80 (surfactant), and PEG (co-surfactant). To the development of best nanoemulsion, three-factor three-level central composite design was used in which %oil; %Smix and % water were optimized as independent variables. An optimized-nanoemulsion were converted to nanoemulsion-Carbopol® 934 gel. Results: 5.5% oil, 35.5% Smix and 59.0% water were optimized as independent and dependent variables. Finally dependent variables optimized as a particle size (nm), PDI and %transmittance were observed 79.92 ± 6.33 nm, 0.229 ± 0.019, and 98.88 ± 1.31% respectively. The values of final results for dependent variables like particle size (nm), PDI and % transmittance were evaluated as 79.92 ± 6.33 nm, 0.229 ± 0.019, and 98.88 ± 1.31%, respectively. TEM and SEM showed a spherical shape of developed nanoemulsion with refractive index (1.63 ± 0.038), zeta potential (−19.16 ± 0.11), pH (7.4 ± 0.06), viscosity (34.28 ± 6 cp), and drug content of 98.8 ± 0.09%. After that a final optimized EUG-NE-Gel was assessed on the basis of their pH measurement, drug content, syringeability, and mucoadhesion on the goat buccal mucosa. Optimized EUG-NE-Gel (Tween-80 and Carbopol® 934 used) showed the results, to improve the periodontal drug delivery of EUG in future. Conclusion: EUG-NE-Gel showed a significant role in anti-inflammatory activity, analgesic, and anesthetic, antibacterial, and treatment of periodontal disease. Keywords: Eugenol, Nanoemulsion-gel, Mucoadhesion, Anti-inflammatory & periodontal disease | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Saudi Pharmaceutical Journal, Vol 27, Iss 6, Pp 778-790 (2019) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1319016419300702 | |
| 787 | 0 | |n https://doaj.org/toc/1319-0164 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8e4de1b66652485295f79d2d8bb5a3e5 |z Connect to this object online. |