Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate
IntroductionThe method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and...
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Frontiers Media S.A.,
2024-10-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Cem Öziç |e author |
| 700 | 1 | 0 | |a Erdal Ertaş |e author |
| 700 | 1 | 0 | |a Mehmet Fırat Baran |e author |
| 700 | 1 | 0 | |a Ayşe Baran |e author |
| 700 | 1 | 0 | |a Elham Ahmadian |e author |
| 700 | 1 | 0 | |a Aziz Eftekhari |e author |
| 700 | 1 | 0 | |a Aziz Eftekhari |e author |
| 700 | 1 | 0 | |a Rovshan Khalilov |e author |
| 700 | 1 | 0 | |a Elvin Aliyev |e author |
| 700 | 1 | 0 | |a Mahmut Yıldıztekin |e author |
| 245 | 0 | 0 | |a Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate |
| 260 | |b Frontiers Media S.A., |c 2024-10-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2024.1482130 | ||
| 520 | |a IntroductionThe method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer.MethodsIn this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles.ResultsCharacterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line.DiscussionWe studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site. | ||
| 546 | |a EN | ||
| 690 | |a morin hydrate | ||
| 690 | |a MCF-7 | ||
| 690 | |a anticancer activity | ||
| 690 | |a magnetic nanocomposite | ||
| 690 | |a drug delivery | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 15 (2024) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2024.1482130/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8e51e5a397ec4dc8979d771a9b6e8fc6 |z Connect to this object online. |