Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

• Main Authors: Immke David C (Author), Wang Weiya (Author), Gao BaoXi (Author), Tamir Rami (Author), Klionsky Lana (Author), Nishimura Nobuko (Author), Gavva Narender R (Author)
• Format: Book
• Published: SAGE Publishing, 2007-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body. Failure of AIT...