Analgesic and antibutyrylcholinestrasic activities of the venom prepared from the Mediterranean jellyfish Pelagia noctiluca (Forsskal, 1775)
<p>Abstract</p> <p>Background</p> <p>Toxins derived from jellyfishes have been exploited as a model for the development of new drug promising applications to treat neurodegenerative diseases. The present work is aimed to evaluate the acute toxicity of crude venom of <...
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| Main Authors: | , , , , |
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| Format: | Book |
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BMC,
2012-06-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Toxins derived from jellyfishes have been exploited as a model for the development of new drug promising applications to treat neurodegenerative diseases. The present work is aimed to evaluate the acute toxicity of crude venom of <it>Pelagia noctiluca</it> and then to screen the analgesic and antibutyrylcholinestrasic (anti-BuChE) activities of the crude venom and its fractions.</p> <p>Methods</p> <p>Sephadex G75 gel was used to separate crude venom of <it>Pelagia noctiluca</it>, which led to some fractions. In addition, <it>in vivo</it> analgesic and <it>in vitro</it> plasma antibutyrylcholinestrasic activities were carried out with <it>Pelagia</it> crude venom and its fractions respectively.</p> <p>Results</p> <p>The crude venom and its fractions displayed analgesic and anti-BuChE activities at different doses without inducing acute toxicity. Fraction 2 possesses the highest analgesic and antibutyrylcholinestrasic properties. The crude venom and fraction 1 had shown to possess less significant inhibitory activity against analgesic and antibutyrylcholinestrasic models.</p> <p>Conclusions</p> <p>Based on this study, the crude venom of <it>Pelagia noctiluca</it> is found to be a useful tool for probing pharmacological activity. The purification and the determination of chemical structures of compounds of active fractions of the venom are under investigation.</p> |
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| Item Description: | 10.1186/1476-0711-11-15 1476-0711 |