Oxidation of Polyunsaturated Fatty Acids as a Promising Area of Research in Infertility
In this review, the role of fatty acids (FA) in human pathological conditions, infertility in particular, was considered. FA and FA-derived metabolites modulate cell membrane composition, membrane lipid microdomains and cell signaling. Moreover, such molecules are involved in cell death, immunologic...
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MDPI AG,
2022-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_8e8b07819b49431c99b94c90daab920d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Giulia Collodel |e author |
| 700 | 1 | 0 | |a Elena Moretti |e author |
| 700 | 1 | 0 | |a Daria Noto |e author |
| 700 | 1 | 0 | |a Roberta Corsaro |e author |
| 700 | 1 | 0 | |a Cinzia Signorini |e author |
| 245 | 0 | 0 | |a Oxidation of Polyunsaturated Fatty Acids as a Promising Area of Research in Infertility |
| 260 | |b MDPI AG, |c 2022-05-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox11051002 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a In this review, the role of fatty acids (FA) in human pathological conditions, infertility in particular, was considered. FA and FA-derived metabolites modulate cell membrane composition, membrane lipid microdomains and cell signaling. Moreover, such molecules are involved in cell death, immunological responses and inflammatory processes. Human health and several pathological conditions are specifically associated with both dietary and cell membrane lipid profiles. The role of FA metabolism in human sperm and spermatogenesis has recently been investigated. Cumulative findings indicate F<sub>2</sub> isoprostanes (oxygenated products from arachidonic acid metabolism) and resolvins (lipid mediators of resolution of inflammation) as promising biomarkers for the evaluation of semen and follicular fluid quality. Advanced knowledge in this field could lead to new scenarios in the treatment of infertility. | ||
| 546 | |a EN | ||
| 690 | |a diet | ||
| 690 | |a fatty acids | ||
| 690 | |a F<sub>2</sub>-isoprostanes | ||
| 690 | |a inflammation | ||
| 690 | |a male infertility | ||
| 690 | |a sperm quality resolvins | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 11, Iss 5, p 1002 (2022) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/11/5/1002 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8e8b07819b49431c99b94c90daab920d |z Connect to this object online. |