The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

• Asıl Yazarlar: Katarina Marcinko (Yazar), Adam L. Bujak (Yazar), James S.V. Lally (Yazar), Rebecca J. Ford (Yazar), Tammy H. Wong (Yazar), Brennan K. Smith (Yazar), Bruce E. Kemp (Yazar), Yonchu Jenkins (Yazar), Wei Li (Yazar), Todd M. Kinsella (Yazar), Yasumichi Hitoshi (Yazar), Gregory R. Steinberg (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2015-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial complex-I inhibitor that has recently been shown to acutely activate AMPK in myotubes. Our main objective was to examin...