Population pharmacokinetics of ivermectin after mass drug administration in lymphatic filariasis endemic communities of Tanzania

• Main Authors: Adam M. Fimbo (Author), Eulambius M. Mlugu (Author), Eliford Ngaimisi Kitabi (Author), Gerald S. Kulwa (Author), Mohammed A. Iwodyah (Author), Rajabu Hussein Mnkugwe (Author), Peter P. Kunambi (Author), Alpha Malishee (Author), Appolinary A. R. Kamuhabwa (Author), Omary M. Minzi (Author), Eleni Aklillu (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ivermectin (IVM) is a drug of choice used with albendazole for mass drug administration (MDA) to halt transmission of lymphatic filariasis. We investigated IVM pharmacokinetic (PK) variability for its dose optimization during MDA. PK samples were collected at 0, 2, 4, and 6 h from individua...