Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease

• Main Authors: Chuanyu Yu (Author), Xueyan Liu (Author), Bingxiang Ma (Author), Jiexin Xu (Author), Yiquan Chen (Author), Chaoxian Dai (Author), Huaping Peng (Author), Daijun Zha (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractButyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases and neuroinflammation. The op...