Cover Image

Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease

AbstractButyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases and neuroinflammation. The op...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chuanyu Yu (Author), Xueyan Liu (Author), Bingxiang Ma (Author), Jiexin Xu (Author), Yiquan Chen (Author), Chaoxian Dai (Author), Huaping Peng (Author), Daijun Zha (Author)
Format:	Book
Published:	Taylor & Francis Group, 2024-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor
by: Shouyuan Sun, et al.
Published: (2022)

Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease
by: Ana Matošević, et al.
Published: (2022)

2-Phenitidine derivatives as suitable inhibitors of butyrylcholinesterase
by: Muhammad Athar Abbasi, et al.
Published: (2013)

Aaptamine - a dual acetyl - and butyrylcholinesterase inhibitor as potential anti-Alzheimer's disease agent
by: Shuang Miao, et al.
Published: (2022)

Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease
by: Hongsong Chen, et al.
Published: (2023)

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
by: Stane Pajk, et al.
Published: (2020)

Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors Based on the Pyridyl-Pyridazine Moiety for the Potential Treatment of Alzheimer's Disease
by: Mohamed Elsawalhy, et al.
Published: (2024)

Bioactive Naphtho-α-Pyranones from Two Endophytic Fungi of the Genus <i>Polyphilus</i>
by: Jan-Peer Wennrich, et al.
Published: (2023)

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease
by: Bushra Shal, et al.
Published: (2018)

Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease
by: Galina F. Makhaeva, et al.
Published: (2023)

Novel Inhibitors of Acetyl- and Butyrylcholinesterase Derived from Benzohydrazides: Synthesis, Evaluation and Docking Study
by: Neto-Honorius Houngbedji, et al.
Published: (2023)

Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
by: Zeynep Soyer, et al.
Published: (2017)

Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
by: İlhami Gulçin, et al.
Published: (2017)

Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model
by: Xiu-Jiang Du, et al.
Published: (2020)

Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
by: Kaitlyn N. Alcorn, et al.
Published: (2024)

Structural Insight of New Butyrylcholinesterase Inhibitors Based on Benzylbenzofuran Scaffold
by: Giovanna L. Delogu, et al.
Published: (2022)

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer's Disease
by: Francisca Cornejo, et al.
Published: (2013)

Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
by: Noor Atatreh, et al.
Published: (2019)

Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors
by: Martina Bortolami, et al.
Published: (2022)

Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative
by: David Bibi, et al.
Published: (2019)

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
by: Raquel B. M. de Almeida, et al.
Published: (2023)

Quinuclidine-Based Carbamates as Potential CNS Active Compounds
by: Ana Matošević, et al.
Published: (2021)

α-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives
by: Jelena B. Popović-Djordjević, et al.
Published: (2017)

Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
by: Huseyin Cavdar, et al.
Published: (2019)

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer's disease based on the neuroinflammatory
by: Zhihan Chen, et al.
Published: (2024)

Quantification of Organophosphate and Carbamate residue on stored grains in Ondo State, Nigeria
by: Akinneye Joseph O, et al.
Published: (2018)

Aqueous extract of Securidaca longipendunculata Oliv. and Olax subscropioidea inhibits key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with Alzheimer's disease in vitro
by: Jamiu A. Saliu, et al.
Published: (2017)

Butyrylcholinesterase level in poisoned patients by phosphide compounds
by: Saeed Afzali, et al.
Published: (2019)

Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening
by: Khalid A. Agha, et al.
Published: (2022)

Design, Synthesis, and Biological Evaluation of 4,4'-Difluorobenzhydrol Carbamates as Selective M<sub>1</sub> Antagonists
by: Jonas Kilian, et al.
Published: (2022)

Molecular Multi-Target Approach for Human Acetylcholinesterase, Butyrylcholinesterase and <i>β</i>-Secretase 1: Next Generation for Alzheimer's Disease Treatment
by: Géssica Oliveira Mendes, et al.
Published: (2023)

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis
by: Qiong Xie, et al.
Published: (2017)

Potential anti-neuroinflammatory NF-кB inhibitors based on 3,4-dihydronaphthalen-1(2H)-one derivatives
by: Yue Sun, et al.
Published: (2020)

Discovery of a Selective 6-Hydroxy-1, 4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring
by: You Zhou, et al.
Published: (2020)

Glutamate Receptors in Neuroinflammatory Demyelinating Disease
Published: (2006)

Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases
by: Isabel Vieira de Assis Lima, et al.
Published: (2012)

Glutamate Receptors in Neuroinflammatory Demyelinating Disease
by: Christopher Bolton, et al.
Published: (2006)

Delipidation of Plasma Has Minimal Effects on Human Butyrylcholinesterase
by: Seda Onder, et al.
Published: (2018)

Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia
by: Lukáš Čuchráč, et al.
Published: (2023)

Development of Novel Fluorinated Polyphenols as Selective Inhibitors of DYRK1A/B Kinase for Treatment of Neuroinflammatory Diseases including Parkinson's Disease
by: Gian Luca Araldi, et al.
Published: (2023)