Encapsulation of Alpha-Lipoic Acid in Functional Hybrid Liposomes: Promising Tool for the Reduction of Cisplatin-Induced Ototoxicity

• Main Authors: Manuela Curcio (Author), Giuseppe Cirillo (Author), Rosario Amato (Author), Lorenzo Guidotti (Author), Diana Amantea (Author), Michele De Luca (Author), Fiore Pasquale Nicoletta (Author), Francesca Iemma (Author), Mercedes Garcia-Gil (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, in order to address the drawback of cisplatin (CDDP)-induced ototoxicity, we propose a straightforward strategy based on the delivery of a sulfur-based antioxidant, such as lipoic acid (LA), to HEI-OC1 cells. To this aim, hybrid liposomes (LA@PCGC) with a spherical shape and a mean di...