Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

• Main Authors: Muhammad Qamar Saeed (Author), Noelle Dufour (Author), Cynthia Bartholmae (Author), Urzula Sieranska (Author), Malaika Knopf (Author), Eloïse Thierry (Author), Sylvain Thierry (Author), Olivier Delelis (Author), Nicolas Grandchamp (Author), Héloïse Pilet (Author), Philippe Ravassard (Author), Julie Massonneau (Author), Françoise Pflumio (Author), Christof von Kalle (Author), François Lachapelle (Author), Alexis-Pierre Bemelmans (Author), Manfred Schmidt (Author), Ché Serguera (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes raises several conceptual and safety issues. To a...