Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

• Main Authors: Hesham Haffez (Author), Nosaiba A. Elsayed (Author), Marwa F. Ahmed (Author), Samar S. Fatahala (Author), Eman F. Khaleel (Author), Rehab Mustafa Badi (Author), Eslam B. Elkaeed (Author), Mahmoud A. El Hassab (Author), Sherif F. Hammad (Author), Wagdy M. Eldehna (Author), Nicolas Masurier (Author), Radwan El-Haggar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Significant advancements have been made in the domain of targeted anticancer therapy for the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal involvement in angiogenesis and subsequent mechanisms that promote tumour cells survival. Herein, novel N-arylmethyl-anilin...