Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to ex...

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Asıl Yazarlar: Apichaya Thontham (Yazar), Rapin Polsook (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: Belitung Raya Foundation, 2021-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Apichaya Thontham  |e author 
700 1 0 |a Rapin Polsook  |e author 
245 0 0 |a Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand 
260 |b Belitung Raya Foundation,   |c 2021-06-01T00:00:00Z. 
500 |a 2477-4073 
500 |a 10.33546/bnj.1337 
520 |a Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients. Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test. Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33). Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life. Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M). 
546 |a EN 
690 |a adverse drug reaction 
690 |a pulmonary tuberculosis 
690 |a symptom experiences 
690 |a quality of life 
690 |a drug-related side effects 
690 |a nursing 
690 |a thailand 
690 |a Nursing 
690 |a RT1-120 
655 7 |a article  |2 local 
786 0 |n Belitung Nursing Journal, Vol 7, Iss 3, Pp 195-202 (2021) 
787 0 |n https://belitungraya.org/BRP/index.php/bnj/article/view/1337 
787 0 |n https://doaj.org/toc/2477-4073 
856 4 1 |u https://doaj.org/article/8fe93a3f89fc49fdaa5ad9321313f81b  |z Connect to this object online.