Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to ex...
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Belitung Raya Foundation,
2021-06-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_8fe93a3f89fc49fdaa5ad9321313f81b | ||
042 | |a dc | ||
100 | 1 | 0 | |a Apichaya Thontham |e author |
700 | 1 | 0 | |a Rapin Polsook |e author |
245 | 0 | 0 | |a Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand |
260 | |b Belitung Raya Foundation, |c 2021-06-01T00:00:00Z. | ||
500 | |a 2477-4073 | ||
500 | |a 10.33546/bnj.1337 | ||
520 | |a Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients. Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test. Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33). Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life. Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M). | ||
546 | |a EN | ||
690 | |a adverse drug reaction | ||
690 | |a pulmonary tuberculosis | ||
690 | |a symptom experiences | ||
690 | |a quality of life | ||
690 | |a drug-related side effects | ||
690 | |a nursing | ||
690 | |a thailand | ||
690 | |a Nursing | ||
690 | |a RT1-120 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Belitung Nursing Journal, Vol 7, Iss 3, Pp 195-202 (2021) | |
787 | 0 | |n https://belitungraya.org/BRP/index.php/bnj/article/view/1337 | |
787 | 0 | |n https://doaj.org/toc/2477-4073 | |
856 | 4 | 1 | |u https://doaj.org/article/8fe93a3f89fc49fdaa5ad9321313f81b |z Connect to this object online. |