Modeling of the controlled release of betacarotene into anhydrous ethanol from microcapsules

• Main Authors: Jucelio Kilinski Tavares (Author), Antônio Augusto Ulson de Souza (Author), José Vladimir de Oliveira (Author), Wagner Luiz Priamo (Author), Selene M.A. Guelli Ulson de Souza (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2352-9520; 10.1016/j.onano.2016.05.001
• Keywords: Controlled release; Microcapsules; Modeling; Active principles; Simulation; Therapeutics. Pharmacology; RM1-950
• Source: OpenNano, Vol 1, Iss C, Pp 25-35 (2016)

In this paper several models of the mass transfer process are described with the aim of simulating the release of active principles from matrix-type polymeric microcapsules. The following mathematical models, which are available in the literature, are applied in this study: Fick's second law (CDMASSA), the linear drive force (LDF), an analytical model and other semi-empirical models. The release of the active principle (betacarotene) contained in microcapsules (PHBV) into a solvent (ethanol) was investigated. It was observed that the model obtained with Fick's second law provided a better fit with the literature data compared with the LDF model, the analytical model and the semi-empirical models. It can be concluded from this finding that the most complete model, based on the phenomenology of the problem, provided the best result.