Phosphodiester Conjugation of Metronidazole and Dexamethasone as Possible Mutual Prodrug

As possible mutual prodrug had been synthesized that contain metronidazole and dexamethazone conjugated through phosphodiester linkage. The rationale for this type of conjugate is to get a prodrug with possible site â€" specific delivery of its active constituents into the lower parts of the G....

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Hauptverfasser: Muthana D. Saud (VerfasserIn), Suhair M. Ghani (VerfasserIn)
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Veröffentlicht: College of Pharmacy University of Baghdad, 2017-03-01T00:00:00Z.
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100 1 0 |a Muthana D. Saud  |e author 
700 1 0 |a Suhair M. Ghani  |e author 
245 0 0 |a Phosphodiester Conjugation of Metronidazole and Dexamethasone as Possible Mutual Prodrug 
260 |b College of Pharmacy University of Baghdad,   |c 2017-03-01T00:00:00Z. 
500 |a 2521-3512 
500 |a 1683-3597 
520 |a As possible mutual prodrug had been synthesized that contain metronidazole and dexamethazone conjugated through phosphodiester linkage. The rationale for this type of conjugate is to get a prodrug with possible site â€" specific delivery of its active constituents into the lower parts of the G.I.T. This compound was synthesized by the reaction of dexamethzone â€" 21 â€" phosphate with metronidazole to form:(1 â€" (dexamethazone â€" 21 â€" phosphoryl) â€" metronidazole)    This conjugate was performed using dicyclohexylcarbodiimide (DCC) as a condensing agent. The identity of the prepared compound had been confirmed using T.L.C., U.V. spectroscopy, IR spectroscopy and elemental analysis. The partition coefficient for it had also been determined through n â€" Octanol / water partitioning system. 
546 |a EN 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Iraqi Journal of Pharmaceutical Sciences, Vol 15, Iss 1 (2017) 
787 0 |n https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/300 
787 0 |n https://doaj.org/toc/2521-3512 
787 0 |n https://doaj.org/toc/1683-3597 
856 4 1 |u https://doaj.org/article/8fee7b1e502841eda84d3399daba920f  |z Connect to this object online.