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Exploring the Anti-Cancer Mechanism of Novel 3,4'-Substituted Diaryl Guanidinium Derivatives

We previously identified a guanidinium-based lead compound that inhibited BRAF through a hypothetic type-III allosteric mechanism. Considering the pharmacophore identified in this lead compound (i.e., "lipophilic group", "di-substituted guanidine", "phenylguanidine polar end...

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Main Authors: Viola Previtali (Author), Helene B. Mihigo (Author), Rebecca Amet (Author), Anthony M. McElligott (Author), Daniela M. Zisterer (Author), Isabel Rozas (Author)
Format: Book
Published: MDPI AG, 2020-12-01T00:00:00Z.
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