Genomic Analysis of <i>Klebsiella pneumoniae</i> ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region

• Main Authors: Tiago Barcelos Valiatti (Author), Rodrigo Cayô (Author), Fernanda Fernandes Santos (Author), Francisco Ozório Bessa-Neto (Author), Ramon Giovani Brandão Silva (Author), Ruanita Veiga (Author), Márcia de Nazaré Miranda Bahia (Author), Lívia Maria Guimarães Dutra Guerra (Author), Antônio Carlos Campos Pignatari (Author), Cintya de Oliveira Souza (Author), Danielle Murici Brasiliense (Author), Ana Cristina Gales (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This study aimed to characterize a <i>Klebsiella pneumoniae</i> strain (KP411) recovered from the stool samples of poultry (<i>Gallus gallus</i>) in the Brazilian Amazon Region. The whole-genome sequencing of KP411 revealed the presence of an important arsenal of antimicrobial resistance genes to β-lactams (<i>bla</i>_CTX-M-14, <i>bla</i>_TEM-1B, <i>bla</i>_KPC-2, <i>bla</i>_SVH-11), aminoglycosides [<i>aph(3")- Ib, aph(6)-Id, aph(3')-Ia</i>], sulfonamides (<i>sul1, sul2</i>), quinolones (<i>oqxAB</i>), fosfomycin (<i>fosA</i>^KP), and macrolides [<i>mph(A)</i>]. Furthermore, our analyses revealed that the KP411 strain belongs to the ST258 clonal lineage, which is one of the main epidemic clones responsible for the dissemination of KPC-2 worldwide. Our data suggest that food-producing animals may act as reservoirs of multidrug-resistant <i>K. pneumoniae</i> belonging to the ST258 clone, and, consequently, contribute to their dissemination to humans and the environment.

Item Description

10.3390/antibiotics11121835
2079-6382