Evaluation of Ribavirin-Poloxamer Microparticles for Improved Intranasal Absorption

• Main Authors: Dipy M. Vasa (Author), Zainab Bakri (Author), Maureen D. Donovan (Author), Lauren A. O'Donnell (Author), Peter L. D. Wildfong (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood-brain barrier, has limited effectiveness in treating viruses affecting the central nervous system. Direct nose-to-brain delivery was investigated for ribavirin in combination with poloxamer 188, an excip...