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Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome

Gut microbial composition alters in some special situations, such as in ulcerative colits (UC) after total proctocolectomy and ileal pouch-anal anastomosis (IPAA) surgery. The aim of our study was to determine the composition of the intestinal microbiome in UC patients after IPAA surgery, compared w...

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Main Authors: Anita Bálint (Author), Klaudia Farkas (Author), Orsolya Méhi (Author), Bálint Kintses (Author), Bálint Márk Vásárhelyi (Author), Eszter Ari (Author), Csaba Pál (Author), Tamara Madácsy (Author), József Maléth (Author), Kata Judit Szántó (Author), István Nagy (Author), Mariann Rutka (Author), Péter Bacsur (Author), Diána Szűcs (Author), Zoltán Szepes (Author), Ferenc Nagy (Author), Anna Fábián (Author), Renáta Bor (Author), Ágnes Milassin (Author), Tamás Molnár (Author)
Format: Book
Published: MDPI AG, 2020-10-01T00:00:00Z.
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Summary:Gut microbial composition alters in some special situations, such as in ulcerative colits (UC) after total proctocolectomy and ileal pouch-anal anastomosis (IPAA) surgery. The aim of our study was to determine the composition of the intestinal microbiome in UC patients after IPAA surgery, compared with UC patients, familial adenomatous polyposis (FAP) patients after IPAA surgery and healthy controls. Clinical data of patients, blood and faecal samples were collected. Faecal microbiota structure was determined by sequencing the V4 hypervariable region of the 16S rRNA gene. Overall, 56 patients were enrolled. Compared to the Healthy group, both the Pouch active and UC active groups had higher <i>Enterobacteriaceae</i>, <i>Enterococcaceae</i> and <i>Pasteurellaceae</i> abundance. The Pouch and UC groups showed distinct separation based on their alpha and beta bacterial diversities. The UC group had higher <i>Prevotellaceae</i>, <i>Rikenellaceae</i>, <i>Ruminococcaceae</i> abundance compared to the Pouch active group. Pouch and FAP participants showed similar bacterial community composition. There was no significant difference in the bacterial abundance between the active and inactive subgroups of the Pouch or UC groups. Gut microbiome and anatomical status together construct a functional unit that has influence on diversity, in addition to intestinal inflammation that is a part of the pathomechanism in UC.
Item Description:10.3390/ph13110346
1424-8247

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