Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

• Hoofdauteurs: Hanxue Wang (Auteur), Min Xuan (Auteur), Juanjuan Diao (Auteur), Nan Xu (Auteur), Manlin Li (Auteur), Cheng Huang (Auteur), Changhong Wang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns. This study aimed to clarify the metabolic pathway of UA and BA and illuminate the relationship between metabolism and t...