Teratogenic effect of cadmium: From the developing embryo to the fetus
Cadmium is recognized as a toxic metal recognized by the United Nations Organization list, and also a potential teratogen in humans. Objective: Of this study was to review the teratogenic effects of Cd in the human embryonic development from pre implantation, implantation and post implantation, and...
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| Main Authors: | , , , |
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| Format: | Book |
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Universidad Libre,
2015-06-01T00:00:00Z.
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| Summary: | Cadmium is recognized as a toxic metal recognized by the United Nations Organization list, and also a potential teratogen in humans. Objective: Of this study was to review the teratogenic effects of Cd in the human embryonic development from pre implantation, implantation and post implantation, and impact on the placenta and fetus. Methodology: The levels of ingestion varies by country, being seafood and tobacco smoke the principal reported sources. This metal has a long half-life, ranging from 75 days to 26 years, and is associated in humans to many cancers. Results: The teratogenic impact of cadmium in each stage of the developing embryo is clear in animal models, but not in humans. Conclusions: In the pre-implantation phase it affects the progression from the two-cell stages to morula; in the implantation phase it affects the trophoblastic invasion; in post-implantation phase it affects organogenesis; in the placenta it decrease Zinc levels in the fetus. |
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| Item Description: | 10.18041/2322-634X/rcso.2.2015.4898 2322-634X |