Determination of the Biochemical Activity of N-Acetyltransferase Enzyme, NAT2 Gene Production in Children with Environmental Pathology Following Received Treatment

• Main Author: N.R. Kech (Author)
• Format: Book
• Published: Zaslavsky O.Yu., 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The study of the biochemical activity of the enzyme N-acetyltransferase, NAT2 gene production in children from ecologically unfavorable regions (EUR) is extremely important to identify predisposition to environmental pathology, including thyroid, renal and urinary diseases, in a contaminated environment. An example of this region is chemically contaminated Halytskyi, Dolynskyi and Kaluskyi districts and radiologically contaminated Sniatyn district of the Ivano-Frankivsk region. We have examined 239 children from EUR and 70 children from the control group. Age of children - 3 to 18 years, sex: boys - 48 %, girls - 52 %. All children were examined clinically, they underwent instrumental (ultrasound investigation, ultrasound densitometry) and laboratory diagnosis before and after therapy. Using biochemical method, we have determined the activity of N-acetyltransferase enzyme. Low acti­vity of the enzyme encoded by the gene NAT2, in children with environmental pathology causes their low capacity for acetylation, which is the basis for the formation of environment-related diseases of the thyroid gland, bones and kidneys in these children. Membrane-protective, antioxidant, sorption therapy and the use of calcium supplements have a pronounced positive effect on the activity of the enzyme N-acetyltransferase in the blood of the children.

Item Description

2224-0551
2307-1168
10.22141/2224-0551.1.69.2016.73716