Jianpi Huayu Decoction enhances the effect of sorafenib and alleviates adverse events in hepatocellular carcinoma by remodeling the gut microbiota
Background: There is an urgent need for effective treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multi-kinase inhibitor, is the first-line treatment for advanced HCC, which has a modest efficacy due to severe adverse effects (AEs), acquired resistance, and others. Jianpi Huayu D...
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2022-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_90a38b94eaf24bd895e44aee6b1be7ff | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xue Deng |e author |
| 700 | 1 | 0 | |a Yingjie Xie |e author |
| 700 | 1 | 0 | |a Yantong Lu |e author |
| 700 | 1 | 0 | |a Xueyan Li |e author |
| 700 | 1 | 0 | |a Xuan Guo |e author |
| 700 | 1 | 0 | |a Xuhui Huang |e author |
| 700 | 1 | 0 | |a Xiaohe Lan |e author |
| 700 | 1 | 0 | |a Juze Lin |e author |
| 700 | 1 | 0 | |a Wei Tan |e author |
| 700 | 1 | 0 | |a Changjun Wang |e author |
| 245 | 0 | 0 | |a Jianpi Huayu Decoction enhances the effect of sorafenib and alleviates adverse events in hepatocellular carcinoma by remodeling the gut microbiota |
| 260 | |b Elsevier, |c 2022-03-01T00:00:00Z. | ||
| 500 | |a 2667-1425 | ||
| 500 | |a 10.1016/j.prmcm.2022.100057 | ||
| 520 | |a Background: There is an urgent need for effective treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multi-kinase inhibitor, is the first-line treatment for advanced HCC, which has a modest efficacy due to severe adverse effects (AEs), acquired resistance, and others. Jianpi Huayu Decoction (JHD) is a traditional Chinese medicine formulation, effective as an alternative and complementary therapy of HCC. Combined sorafenib with JHD is a potential approach to overcome sorafenib resistance. Methods: Effect and AEs of clinical-dose sorafenib combined JHD were evaluated in a subcutaneous model. Diarrhea, the most frequently reported AEs, was evaluated by diarrhea score. Illumina NovaSeq analyzed the gut microbiota (GM) composition of the mice. Results: JHD administration enhanced anti-tumor response to sorafenib and prevented the occurrence of sorafenib-induced diarrhea and body weight loss. Proinflammatory GM Helicobacter positively correlated with sorafenib treatment while anti-inflammatory GM, Muribaculum, Fusicatenibacter, and Dorea positively correlated with JHD treatment. In addition, JHD decreased the infiltration of inflammatory cells and downregulated signaling of interleukin 6/signal transducer and activator of the transcription-3 pathway. Conclusions: Our finding suggested that JHD with microbiota modulation properties could significantly potentiate sorafenib and provide a promising treatment for advanced HCC. | ||
| 546 | |a EN | ||
| 690 | |a Hepatocellular carcinoma | ||
| 690 | |a Jianpi Huayu | ||
| 690 | |a Decoction | ||
| 690 | |a Sorafenib | ||
| 690 | |a Microbiota | ||
| 690 | |a Other systems of medicine | ||
| 690 | |a RZ201-999 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmacological Research - Modern Chinese Medicine, Vol 2, Iss , Pp 100057- (2022) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2667142522000185 | |
| 787 | 0 | |n https://doaj.org/toc/2667-1425 | |
| 856 | 4 | 1 | |u https://doaj.org/article/90a38b94eaf24bd895e44aee6b1be7ff |z Connect to this object online. |