Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients

• Main Authors: Patrick O. Hanafin (Author), Roger L. Nation (Author), Marc H. Scheetz (Author), Alexandre P. Zavascki (Author), Ana M. Sandri (Author), Andrea L. Kwa (Author), Benjamin P. Z. Cherng (Author), Christine J. Kubin (Author), Michael T. Yin (Author), Jiping Wang (Author), Jian Li (Author), Keith S. Kaye (Author), Gauri G. Rao (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Polymyxin B (PMB) has reemerged as a last‐line therapy for infections caused by multidrug‐resistant gram‐negative pathogens, but dosing is challenging because of its narrow therapeutic window and pharmacokinetic (PK) variability. Population PK (POPPK) models based on suitably powered clinic...