Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab

• Үндсэн зохиолчид: Blaise Pasquiers (Зохиогч), Salih Benamara (Зохиогч), Mathieu Felices (Зохиогч), David Ternant (Зохиогч), Xavier Declèves (Зохиогч), Alicja Puszkiel (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2023-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Interspecies translation of monoclonal antibodies (mAbs) pharmacokinetics (PK) in presence of target-mediated drug disposition (TMDD) is particularly challenging. Incorporation of TMDD in physiologically based PK (PBPK) modeling is recent and needs to be consolidated and generalized to provide bette...