Challenges in diagnostic research of multisystem inflammatory syndrome in children associated with COVID-19 in combination with the early stage of Epstein-Barr virus infection

• Main Authors: Е. А. Kashirina (Author), N. M. Yugay (Author), O. B. Karabanova (Author), L. V. Markina (Author), E. V. Babenko (Author), S. G. Zagidullina (Author), O. A. Lomakina (Author), N. I. Kolganova (Author), A. A. Glazyrina (Author), Yu. Yu. Novikova (Author), A. E. Andzhel (Author), Yu. V. Romanova (Author), A. Yu. Rtischev (Author), D. Yu. Ovsyannikov (Author), V. V. Gorev (Author)
• Format: Book
• Published: LLC "Diagnostics and Vaccines", 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare life-threatening immunopathological complication of COVID-19 that develops 1-6 weeks after the acute coronavirus infection. MIS-C is characterized by fever and multiorgan inflammation.We present a clinical case of a 10-year-old boy with skin lesions at the onset of MIS-C (erythematous malar rash, lacelike rash on the trunk and extremities and petechiae) with macrophage activation syndrome development and the early stage of primary Epstein-Barr virus infection (EBV infection) which required the exclusion of X-linked lymphoproliferative disease.This clinical case demonstrates the complexity of diagnosis in MIS-C with skin manifestations at the onset of the disease, especially with concurrent activation of other infections, particularly EBV infection.

Item Description

2072-8107
10.22627/2072-8107-2022-21-2-51-56