Cover Image

Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer

Cervical cancer is the fourth leading cancer type and the second most common gynecological malignancy among women worldwide. Silibinin (SB), a chief bioactive natural polyphenolic flavonoid of Silybum marianum L., has been used clinically for its hepatocyte protective effects. It also has anticancer...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yanting You (Author), Qiuxing He (Author), Hanqi Lu (Author), Xinghong Zhou (Author), Liqian Chen (Author), Huaxi Liu (Author), Zibin Lu (Author), Dongyi Liu (Author), Yanyan Liu (Author), Daming Zuo (Author), Xiuqiong Fu (Author), Hiuyee Kwan (Author), Xiaoshan Zhao (Author)
Format:	Book
Published:	Frontiers Media S.A., 2020-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review
by: Liqian Chen, et al.
Published: (2021)

Liang-Ge-San, a Classic Traditional Chinese Medicine Formula, Attenuates Lipopolysaccharide-Induced Acute Lung Injury Through Up-Regulating miR-21
by: Huayi Yang, et al.
Published: (2019)

Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission
by: Nanshan Song, et al.
Published: (2021)

Corrigendum: Induced expression of kir6.2 in A1 astrocytes propagates inflammatory neurodegeneration via Drp1-dependent mitochondrial fission
by: Nanshan Song, et al.
Published: (2023)

Assessment of resident physicians satisfaction on residency training in Southwest China:A cross-sectional study
by: Lulin Chen, et al.
Published: (2024)

Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells
by: Tong Xu, et al.
Published: (2021)

Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1
by: Yan Hu, et al.
Published: (2022)

Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology
by: Bong Sook Jhun, et al.
Published: (2018)

Correction to: Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells
by: Tong Xu, et al.
Published: (2022)

Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway
by: Yayun Liu, et al.
Published: (2019)

Silibinin alleviates intestinal inflammation via inhibiting JNK signaling in Drosophila
by: La Yan, et al.
Published: (2023)

Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis
by: You Wu, et al.
Published: (2019)

Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1Ser616 Phosphorylation-Mediated Mitochondrial Fission
by: Li Chen, et al.
Published: (2020)

The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR
by: Janos Steffen, et al.
Published: (2022)

NSD2 modulates Drp1-mediated mitochondrial fission in chronic renal allograft interstitial fibrosis by methylating STAT1
by: Jianjian Zhang, et al.
Published: (2024)

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells
by: Kecheng Zhou, et al.
Published: (2019)

Liquiritin exhibits anti-acute lung injury activities through suppressing the JNK/Nur77/c-Jun pathway
by: Hongling Zhou, et al.
Published: (2023)

Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities
by: Xu R, et al.
Published: (2022)

Ocular fundus manifestation of two patients following long-term chloroquine therapy: a case report
by: He Dongyi, et al.
Published: (2010)

Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system
by: Liqian Ci, et al.
Published: (2017)

CTRP9 Enhances Efferocytosis in Macrophages via MAPK/Drp1-Mediated Mitochondrial Fission and AdipoR1-Induced Immunometabolism
by: Song CX, et al.
Published: (2021)

Discovery of Topoisomerase I Inhibitor Nitidine Derivatives with IL-10 Enhancing Activity for the Treatment of Sepsis
by: Siyu Liu, et al.
Published: (2024)

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
by: Liu K, et al.
Published: (2019)

Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications
by: Junhua Li, et al.

Insights Into the Properties, Biological Functions, and Regulation of USP21
by: Tao An, et al.
Published: (2022)

A retrospective study on the characteristics of treating nevus of ota by 1064-nm q-switched neodymium-doped yttrium aluminum garnet laser
by: Yanting Liu, et al.
Published: (2016)

Epidemiological Features of Glycemic Levels and Relative Determinants at Different Altitudes Among Tibetans in China: A Cross-Sectional Population-Based Study
by: Qiuxing Lin, et al.
Published: (2020)

Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?
by: Yanting Lu, et al.
Published: (2021)

Risk Factors and Clinical Characteristics of Neonatal Acute Respiratory Distress Syndrome Caused by Early Onset Sepsis
by: Ting You, et al.
Published: (2022)

Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma
by: Ying Liu, et al.
Published: (2023)

Oocyte quality is closely linked to DRP1 derived-mitochondrial fission and mitophagy by the NAD+ biosynthesis in a postovulatory-aging model of pigs
by: Ji-Hyun Shin, et al.
Published: (2024)

Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice
by: Lin Lin, et al.
Published: (2017)

The effect of COVID-19 vaccination on epileptic seizures in patients with epilepsy: A clinical observation in China
by: Aizhen Huang, et al.
Published: (2022)

A case-control study of the risk factors for fistula-in-ano in infants and toddlers
by: Yanting Sun, et al.
Published: (2024)

Atractylenolide I Inhibits NLRP3 Inflammasome Activation in Colitis-Associated Colorectal Cancer via Suppressing Drp1-Mediated Mitochondrial Fission
by: Yao Qin, et al.
Published: (2021)

Design, Synthesis and Biological Evaluation of Glycosylated Derivatives of Silibinin as Potential Anti-Tumor Agents
by: Xi JJ, et al.
Published: (2023)

Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway
by: Xiaoying Hou, et al.
Published: (2018)

Corrigendum to 'Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells' [J Pharmacol Sci 139 (2019) 15-22]
by: Kecheng Zhou, et al.
Published: (2021)

Tumor-Suppressing STF cDNA 3 Overexpression Suppresses Renal Fibrosis by Alleviating Anoikis Resistance and Inhibiting the PI3K/Akt Pathway
by: Fei Xiao, et al.
Published: (2021)

Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
by: Dongyao Hou, et al.
Published: (2024)