Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer

• Main Authors: Yanting You (Author), Qiuxing He (Author), Hanqi Lu (Author), Xinghong Zhou (Author), Liqian Chen (Author), Huaxi Liu (Author), Zibin Lu (Author), Dongyi Liu (Author), Yanyan Liu (Author), Daming Zuo (Author), Xiuqiong Fu (Author), Hiuyee Kwan (Author), Xiaoshan Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cervical cancer is the fourth leading cancer type and the second most common gynecological malignancy among women worldwide. Silibinin (SB), a chief bioactive natural polyphenolic flavonoid of Silybum marianum L., has been used clinically for its hepatocyte protective effects. It also has anticancer...