Reno-protective and reno-restorative effect of the Epidermal Growth Factor in biomodel of Chronic Renal Failure
<p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; text-autospace: none;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Introduction:</strong> Kidney disease is a world health problem. Epidermic Growth...
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Universidad de Ciencias Médicas de La Habana,
2017-12-01T00:00:00Z.
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| Summary: | <p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; text-autospace: none;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Introduction:</strong> Kidney disease is a world health problem. Epidermic Growth Factor acts as cyto-protector, and trophic restorative.<br /> </span><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Objective: </strong> To assess the reno-protective and reno-restorative effect of the Epidermal Growth Factor in biomodel of Chronic Renal Failure.<br /> </span><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Material and Methods:</strong> 120 Wistar rats were studied in 6 groups: Negative and Positive Control, Saline Solution Single-Dose and Multiple-Dose, Epidermal Growth Factor Single-Dose and Multiple-Dose. A single dose was applied before the damage for the reno-protective effect, and multiple doses after the damage for the reno-restorative effect, at a rate of 100 µg/kg of weight.<br /> </span><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Results: </strong>Creatinine, urea, and uric acid diminished significantly in the experimental groups, with a higher decrease for experimental group with single dose; therefore, the reno-protective effect was higher than reno-restorative one for the treatment patterns used.<br /> </span><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Conclusions:</strong> Epidermal Growth Factor showed reno-protective and reno-restorative effect by diminishing the hematological variables in kidney damage.</span></p><p style="text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Keywords:</strong> Epidermal Growth Factor, reno-protective, reno-restorative, Chronic Renal Failure, 5/6 renal ablation.</span></p> |
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| Item Description: | 1729-519X |