Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex Vivo Tissues

• Main Authors: Fabio Lobascio (Author), Rocco Di Modugno (Author), Marco Fiore (Author), Nicola Di Modugno (Author), Cristian Bruno (Author), Thomas De Nicolo (Author), Rossella Veronica Barberis (Author), Karine Cabiale (Author), Marilena Radoiu (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/ddc3030032; 2813-2998
• Keywords: microwaves; radiofrequency; medical applications; medical equipment; solid-state; tissue ablation; Pharmacy and materia medica; RS1-441; Chemistry; QD1-999
• Source: Drugs and Drug Candidates, Vol 3, Iss 3, Pp 550-565 (2024)

In this paper, we report on the use of a purpose-built hybrid solid-state microwave and radiofrequency generator operating at frequencies of 2.45 GHz and/or 480 kHz for cancer ablation in various tissues. The hybrid generator was tested ex vivo on chicken breast and bovine liver and has demonstrated that the high accuracy of the power delivered to the sample can be achieved by controlling the emitted power versus the temperature profile of the treated sample. In particular, the hybrid generator incorporates control systems based on impedance or reflected power measurements that allow controlled ablation without causing unwanted carbonization and without including areas where tissue damage is not desired. The results of the ex vivo tests showed that radiofrequency ablation (RFA) could be effective for performing controlled ablations with minimally invasive probes, such as cardiac pathologies, small lesions, and tissues with particular composition, while microwave ablation (MWA) could be optimal for performing large ablations in highly vascularized tissues, such as liver cancer, where it is necessary to achieve higher temperatures.